Thursday, November 8, 2012

Nor'easter brings new misery to Northeast

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Source: http://news.yahoo.com/sandy-disrupts-voting-northeast-braces-storm-032835270--sector.html

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Wednesday, November 7, 2012

Cancer data in the 'cloud' could lead to more effective treatment

Cancer data in the 'cloud' could lead to more effective treatment [ Back to EurekAlert! ] Public release date: 6-Nov-2012
[ | E-mail | Share Share ]

Contact: Phil Sneiderman
prs@jhu.edu
443-287-9960
Johns Hopkins University

Storing music and photos on distant computers via "cloud" technology is nothing new. But Johns Hopkins researchers are now using this tactic to collect detailed information from thousands of cancer cell samples. The goal is to help doctors make better predictions about how a patient's illness will progress and what type of treatment will be most effective.

The project, supported by a new $3.75 million National Cancer Institute grant, was launched because researchers now realize that cancer cells affecting the same type of tissue can behave differently in different patients. Prostate cancers may grow rapidly in one patient, but expand at a glacial pace in another. A drug that kills a tumor in one patient may be useless or even harmful in the next patient.

To help doctors prepare a more personalized medical prognosis and treatment plan, Johns Hopkins has assembled experts in cancer and engineering, led by Denis Wirtz , associate director of the university's Institute for NanoBioTechnology. The team has begun characterizing and storing cancer data collected through a process called high-throughput cell phenotyping.

"We use scanning microscopy to take pictures of the size and shape of cancer cells," said Wirtz, who also directs the Johns Hopkins Physical Sciences-Oncology Center. "We also extract information about what is happening inside the cells and at the genetic level. We make notes of the age and gender of the patient and any treatment received. Looked at as a whole, this information can help us identify a 'signature' for a certain type of cancer.

That gives us a better idea of how it spreads and how it responds to certain drugs." He added, "The long-range goal is to make this data available through the Internet to physicians who are diagnosing and treating cancer patients around the world."

Wirtz , a professor of chemical and biomolecular engineering in the university's Whiting School of Engineering, has been working with School of Medicine researchers Ralph Hruban and Anirban Maitra to begin the database with material from the files of thousands of cancer patients who have been evaluated and treated at Johns Hopkins. The patients' personal information has been deleted, but the remaining medical case data allows the researchers to trace the course of the disease from initial testing through treatment and outcome.

"This technology may provide a way to centralize specimen data, images and analysis in a way that hasn't been done before," said Maitra, a professor of pathology and oncology, "and we'll be using the information now to find better ways to treat disease."

The Johns Hopkins team will soon collect similar data from other major U.S. cancer research centers that are also supported by the National Institutes of Health. The initial focus will be pancreatic cancer, which is particularly aggressive and lethal.

"We may be able to correlate DNA changes that occur in individual pancreatic cancer cells with the appearance of these cells at the cellular level," said Hruban, a professor of pathology and oncology and director of the Sol Goldman Pancreatic Cancer Research Center. "The potential for this approach to provide insight into the fundamental biology of pancreatic cancer is significant, as are the potential clinical applications in predicting a patient's prognosis and in guiding therapy."

Other types of the disease, including breast and prostate cancer, will be addressed in the near future. Early data is being stored on computers at the Los Alamos National Laboratory under an arrangement funded by the NIH.

According to Wirtz, the details recorded in the online database will differ from those produced in traditional biopsy evaluations. Typically, information about a patient's disease is obtained by averaging the results from trillions of cells that have been blended together.

With the new scanning system, however, the Johns Hopkins researchers will obtain views of individual cells retrieved from individual patients, even from different parts of the same organ.

This ability to examine single cells is important, Wirtz said, because scientists have discovered that even cells that possess the identical genetic makeup can vary in other small ways that affect the behavior of cancer. For example, these tiny variations in genetically identical cells can cause some to be vulnerable to a particular cancer drug.

"We've come to realize that it is the heterogeneity -- the diversity of cells that have different characteristics -- that is important in evaluating a cancer case," Wirtz said. "In the end, what matters is the cell properties. That's what we measure."

Researchers will begin their studies on clinical samples collected at Johns Hopkins to determine how well the technology works and validate it's potential before it can be used to aid clinical decision-making.

The software and hardware used in the high-throughput cell phenotyping process is protected by patents obtained through the Johns Hopkins Technology Transfer office. The $3.75 million National Cancer Institute grant (CA174388) will be disbursed to the Johns Hopkins Institute for NanoBioTechnology over a five-year period. The funds were allocated through the National Institutes of Health's Common Fund Single Cell Analysis Program.

###

Related links:

Johns Hopkins Institute for NanoBioTechnology: http://inbt.jhu.edu/

Johns Hopkins Engineering in Oncology Center: http://psoc.inbt.jhu.edu/

Johns Hopkins Kimmel Cancer Center: http://www.hopkinsmedicine.org/kimmel_cancer_center/


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Cancer data in the 'cloud' could lead to more effective treatment [ Back to EurekAlert! ] Public release date: 6-Nov-2012
[ | E-mail | Share Share ]

Contact: Phil Sneiderman
prs@jhu.edu
443-287-9960
Johns Hopkins University

Storing music and photos on distant computers via "cloud" technology is nothing new. But Johns Hopkins researchers are now using this tactic to collect detailed information from thousands of cancer cell samples. The goal is to help doctors make better predictions about how a patient's illness will progress and what type of treatment will be most effective.

The project, supported by a new $3.75 million National Cancer Institute grant, was launched because researchers now realize that cancer cells affecting the same type of tissue can behave differently in different patients. Prostate cancers may grow rapidly in one patient, but expand at a glacial pace in another. A drug that kills a tumor in one patient may be useless or even harmful in the next patient.

To help doctors prepare a more personalized medical prognosis and treatment plan, Johns Hopkins has assembled experts in cancer and engineering, led by Denis Wirtz , associate director of the university's Institute for NanoBioTechnology. The team has begun characterizing and storing cancer data collected through a process called high-throughput cell phenotyping.

"We use scanning microscopy to take pictures of the size and shape of cancer cells," said Wirtz, who also directs the Johns Hopkins Physical Sciences-Oncology Center. "We also extract information about what is happening inside the cells and at the genetic level. We make notes of the age and gender of the patient and any treatment received. Looked at as a whole, this information can help us identify a 'signature' for a certain type of cancer.

That gives us a better idea of how it spreads and how it responds to certain drugs." He added, "The long-range goal is to make this data available through the Internet to physicians who are diagnosing and treating cancer patients around the world."

Wirtz , a professor of chemical and biomolecular engineering in the university's Whiting School of Engineering, has been working with School of Medicine researchers Ralph Hruban and Anirban Maitra to begin the database with material from the files of thousands of cancer patients who have been evaluated and treated at Johns Hopkins. The patients' personal information has been deleted, but the remaining medical case data allows the researchers to trace the course of the disease from initial testing through treatment and outcome.

"This technology may provide a way to centralize specimen data, images and analysis in a way that hasn't been done before," said Maitra, a professor of pathology and oncology, "and we'll be using the information now to find better ways to treat disease."

The Johns Hopkins team will soon collect similar data from other major U.S. cancer research centers that are also supported by the National Institutes of Health. The initial focus will be pancreatic cancer, which is particularly aggressive and lethal.

"We may be able to correlate DNA changes that occur in individual pancreatic cancer cells with the appearance of these cells at the cellular level," said Hruban, a professor of pathology and oncology and director of the Sol Goldman Pancreatic Cancer Research Center. "The potential for this approach to provide insight into the fundamental biology of pancreatic cancer is significant, as are the potential clinical applications in predicting a patient's prognosis and in guiding therapy."

Other types of the disease, including breast and prostate cancer, will be addressed in the near future. Early data is being stored on computers at the Los Alamos National Laboratory under an arrangement funded by the NIH.

According to Wirtz, the details recorded in the online database will differ from those produced in traditional biopsy evaluations. Typically, information about a patient's disease is obtained by averaging the results from trillions of cells that have been blended together.

With the new scanning system, however, the Johns Hopkins researchers will obtain views of individual cells retrieved from individual patients, even from different parts of the same organ.

This ability to examine single cells is important, Wirtz said, because scientists have discovered that even cells that possess the identical genetic makeup can vary in other small ways that affect the behavior of cancer. For example, these tiny variations in genetically identical cells can cause some to be vulnerable to a particular cancer drug.

"We've come to realize that it is the heterogeneity -- the diversity of cells that have different characteristics -- that is important in evaluating a cancer case," Wirtz said. "In the end, what matters is the cell properties. That's what we measure."

Researchers will begin their studies on clinical samples collected at Johns Hopkins to determine how well the technology works and validate it's potential before it can be used to aid clinical decision-making.

The software and hardware used in the high-throughput cell phenotyping process is protected by patents obtained through the Johns Hopkins Technology Transfer office. The $3.75 million National Cancer Institute grant (CA174388) will be disbursed to the Johns Hopkins Institute for NanoBioTechnology over a five-year period. The funds were allocated through the National Institutes of Health's Common Fund Single Cell Analysis Program.

###

Related links:

Johns Hopkins Institute for NanoBioTechnology: http://inbt.jhu.edu/

Johns Hopkins Engineering in Oncology Center: http://psoc.inbt.jhu.edu/

Johns Hopkins Kimmel Cancer Center: http://www.hopkinsmedicine.org/kimmel_cancer_center/


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-11/jhu-cdi110612.php

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New PC gamer -- gonna make the switch to KB/M for FPS...tips ...

My suggestion is to get a keypad like the n52te (used to be made by nostromo, now made by razer I think) or the logitech g13. The mouse is easy to get used to IMO, it's the keyboard that really isn't suited for gaming. A keypad has a joystick for movement, which you are used to from controllers, and a condensed button layout.

I've never really liked aiming with a controller, pushing the reticle just never felt right to me, The transition between aiming, the dead space and then player movement always felt unnatural. But accurately clicking on things with a mouse in an FPS always felt intuitive because I was used to it from just using a computer. I would say my time was fairly evenly split growing up between consoles and pc, although I played some FPS's on the PC growing up, the first one I really got into was n64 goldeneye and then I moved onto other console shooters before I eventually went back to gaming on the computer.


Last edited by msdmoney; 11-06-12 at 09:42 PM.

Source: http://forum.dvdtalk.com/video-game-talk/606241-new-pc-gamer-gonna-make-switch-kb-m-fps-tips.html

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Ortiz, Red Sox finalize $26 million, 2-year deal

BOSTON (AP) ? David Ortiz, the face of the Red Sox since helping Boston end an 86-year World Series drought in 2004, has finalized a $26 million, two-year contract.

The soon-to-be 37-year old Ortiz attended a Fenway Park news conference Monday to announce the agreement, which includes bonuses that could raise the value to $30 million.

Big Papi had consecutive game-ending hits in extra innings of Games 4 and 5 of the 2004 AL championship series against the Yankees as the Red Sox became the first major league team to overcome a 0-3 deficit in a best-of-seven postseason series.

The eight-time All-Star has hit 343 homers for Boston, fifth on the team's career list, and has 1,088 RBIs.

Source: http://news.yahoo.com/ortiz-red-sox-finalize-26-million-2-deal-205139555--mlb.html

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Tuesday, November 6, 2012

#9: Koolertron Sound music Activated Car Stickers Equalizer Glow ...

Koolertron Sound music Activated Car Stickers Equalizer Glow Sky-blue Light for cars (900mm x 250mm) by Koolertron Buy new: $65.99 2 used & new from $55.99 (Visit the Hot New Releases in Car Audio list for authoritative information on this product?s current rank.)

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Source: http://www.wiki-products.com/9-koolertron-sound-music-activated-car-stickers-equalizer-glow-sky-blue-light-for-cars-900mm-x-250mm/

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Monday, November 5, 2012

Insurance Won't Cover Damage To Torched SF Muni Bus ? CBS ...

An eyewitness recorded video of a a man torching a Muni bus at the intersection of Market Street & Third Street on October 29, 2012. (SFPD)

An eyewitness recorded video of a a man torching a Muni bus at the intersection of Market Street & Third Street on October 29, 2012. (SFPD)

SAN FRANCISCO (CBS SF) ? San Francisco Municipal Railway is out about $1 million because its insurance does not cover the damage caused by vandals who set a bus on fire during revelry after the Giants? World Series win, a Muni spokesman said Monday.

The 8X-Bayshore Express bus, which initially cost about $700,000 and had an additional $300,000 in rehabilitative work done on it recently, was set ablaze at Market and Third streets about 12:30 a.m. on Oct. 29.

Muni spokesman Paul Rose said the agency?s insurance policy does not cover the damage caused by the arson.

That means Muni is responsible for the tab, aside from any restitution paid by people who may be found responsible for the vandalism.

The bus driver and eight passengers were able to safely escape before the vandals smashed its windows and set the vehicle on fire.

The driver, Alan Yam, will be honored at the San Francisco Municipal Transportation Agency?s board of directors meeting on Tuesday for keeping everyone safe, Rose said.

Those responsible for the arson remain at large but were captured on a video recorded by a bystander. The video was released by police last week and is available online at www.vimeo.com/52506635.

A picture taken by a San Francisco Chronicle photographer helped lead to the arrest of Gregory Tyler Graniss, 22, who police believe smashed the windshield of the bus with part of a police barricade.

Graniss is expected to be arraigned Monday afternoon.

(Copyright 2012 by CBS San Francisco. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed.)

Source: http://sanfrancisco.cbslocal.com/2012/11/05/insurance-wont-cover-damage-to-torched-muni-bus/

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SIP Cloud Services ? Healthcare from the Canada Cloud ? Cloud ...

A key facet of the of the Canada Health Infoway Cloud strategy document, is that it identifies services key to the ?PaaS? (Platform as a Service) layer of Cloud computing.

So it?s a good general intro for product strategy at this layer of the Cloud services stack, especially when built around such a large, high-growth industry like Healthcare.

CEBP Transformation

Service providers who deploy Cloud technology that runs the IP communications procotol ?SIP?, will be able to offer associated hosting options: SIP Cloud Services, providing core features such as:

Making all of these services accessible primarily to an audience of software developers, rather than telecomms managers, is the disruptive shift that PaaS represents.

This reflects a maturity in the industry as well as a step up the Cloud standards model: To date we have mainly experienced an IaaS market, which is a relatively small evolution of the existing web hosting markey. Big in scale but not necessarily revolutionary in terms of software design and delivery methods.

In contrast PaaS will be felt most keenly by software programmers, rather than infrastructure managers; naturally.

CEBP Transformation

To illustrate the point and explain SIP Cloud Services we can look at a special topic from the teleomms industry:?CEBP, standing for Communications Enabled Business Process.

In short this means using Unified Communications capabilities, like voice communications, voicemails, faxing, video conferencing, Presence and Instant Messaging, etc., can be accessible to a programmer then building an overall product set: Healthcare workflows for example.

These are ideal building blocks for more dynamic and collaborate BPM (Business Process Management), and so a set of SIP Cloud Services that offer the functionality would be great apps for these sectors.

Building blocks is the key term, because it`s not traditional telco product > phones, switchboards, .. that comes as physical devices to sell to the office staff, but is rather a catalogue of software components that developers pick and choose from. I.e. An apps store.

Healthcare from the Canada Cloud

The Canada Health Infoway paper sets the scene for services at this layer ? There is a keen focus on business transformation and also more emphasis on the complexities of applications and integrations, rather than the basic IaaS building blocks.

As you might expect the most likely sources of this new layer of PaaS services would come from Canadian based suppliers; however equally the fact it is only software components running on IaaS, it`s also likely USA and other providers will emerge, especially when the platform is so readily accessible and common to all Healthcare markets.

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Source: http://cloudbestpractices.net/2012/11/04/sip-cloud-services-healthcare-from-the-canada-cloud/

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